You will find a release of norepinephrine through the descending inhibitory bulbospinal neurons that binds to alpha-2-receptors while in the dorsal horn to lessen afferent discomfort transmission and make analgesia. Thus, medication like clonidine that focus on alpha-two receptors can affect the transmission of soreness. Applies to clonidine: oral https://atozbookmark.com/story19631654/onolidine-an-overview