DNA ligases seal five′-PO4 and three′-OH polynucleotide ends through three nucleotidyl transfer steps involving ligase-adenylate and DNA-adenylate intermediates. DNA ligases are important guardians of genomic integrity, and ligase dysfunction underlies human genetic disease syndromes. Crystal structures of DNA ligases sure to nucleotide and nucleic acid substrates have illuminated how https://zanekibwo.dailyhitblog.com/33445923/manual-article-review-is-required-for-this-article