DNA ligases seal 5′-PO4 and 3′-OH polynucleotide finishes by way of a few nucleotidyl transfer ways involving ligase-adenylate and DNA-adenylate intermediates. DNA ligases are necessary guardians of genomic integrity, and ligase dysfunction underlies human genetic ailment syndromes. Crystal structures of DNA ligases bound to nucleotide and nucleic acid substrates https://quentinj023cwp7.blogitright.com/profile